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Our latest research explores a novel treatment of a disease that affects a large percent of the older male population. The anti-tumor mechanisms/properties of Typhimurium are extremely promising but to date are unknown. In order to safely and fully convert the potential power of this treatment scheme into a controllable and safe therapy, we must understand how/why it works. This research will increase our insight into understanding the mechanisms by which VNP20009 Typhimurium and other engineered strains affect tumor cells and destroys tumor tissue and without causing harmful side effects. Our ultimate Goal is to develop strategies for creating more specific Typhimurium strains that specifically target prostate cancer.