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A number of promising new strategies are being developed by Columbia scientists for theprevention, diagnosis, and treatment of cancer. The Cancer Research Center provides additional funds for their projects. The scientists and their strategies include:
Radiopharmaceuticals to Target and Destroy Tumors In this strategy, developed at the University of Missouri, drugs are linked up with radioactive metals that specifically attach to tumor cells. First, this can provide a visual image to pinpoint the tumor. Next, the energy emitted from the radioactive metal can then destroy tumor cells.
Basic understanding of what triggers chromosome damage and the repair of that damage Cancers all have one thing in common. All tumors are initiated by damage to DNA. Fortunately, cells have repair mechanisms for repair of this damage. However, in some cases, damages is too great or repair is inadequate, thus cancer develops.
Prostate Tumor Targeting and Killing Mechanisms by Salmonella typhimurium in the Mouse Model Prostate cancer occurs in a latent or clinical form in 30-40% of men by age 40-50, increasing substantially in men over 50 years of age. Current use of drugs and radiation has been partially effective only when the cancer is diagnosed early. Thus, research is needed into novel approaches to cure this devastating disease.
The Cancer Research Center’s (CRC) novel approach utilizes a therapeutic strain of Salmonella typhimurium (CRC2631) to selectively target and destroy prostate tumor cells.
Destruction of tumor cells with novel drugs and toxins
Development of synthetic vaccines and antibodies
Cancer Research Center
3501 Berrywood Drive Columbia, Missouri 65201
Phone: (573) 875-2255 Fax: (573) 443-1202
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