Starting in the late 1940âs, Miloslav Demerec and associates at Cold Spring Harbor Laboratory and Brookhaven National Laboratory stocked an extensive collection of auxotrophic mutants for the purpose of mapping the S. typhimurium LT2 chromosome. Over 10,000 of these original sealed agar stab cultures (0.5 ml/agar stab vial) are now curated in our laboratory at the Cancer Research Center. Information on alleles is from labels on vials or from original notebooks.

Determination of the Role of Estrogen in Colon Cancer Development Using Estrogen Receptors in Knock Out Mice

Prostate cancer occurs in a latent or clinical form in 30-40% of men by age 40-50, increasing substantially in men over 50 years of age. Current use of drugs and radiation has been partially effective only when the cancer is diagnosed early. Thus, research is needed into novel approaches to cure this devastating disease. The Cancer Research Center’s (CRC) novel approach utilizes a therapeutic strain of Salmonella typhimurium (CRC2631) to selectively target and destroy prostate tumor cells.

In this strategy, developed at the University of Missouri, drugs are linked up with radioactive metals that specifically attach to tumor cells. First, this can provide a visual image to pinpoint the tumor. Next, the energy emitted from the radioactive metal can then destroy tumor cells.

Cancers all have one thing in common. All tumors are initiated by damage to DNA. Fortunately, cells have repair mechanisms for repair of this damage. However, in some cases, damages is too great or repair is inadequate, thus cancer develops.

Chemical and Biochemical Reactions of Dithiolethiones in Certain Foods